Insights on Alzheimer’s Research and Prevention

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KNOW YOUR ALZHEIMER’S RISKS: #2 GUM DISEASE

If we described Periodontal Disease, you’d think we were describing Alzheimer’s Periodontal Disease (PD) is painless and often goes undetected until damage has already occurred. PD is a disease of inflammation. This disease produces something called “plaque” which is a sticky, destructive biofilm that in the mouth covers the tooth surface. PD is considered an age-related disease and increases in incidence the older you are. Periodontal Disease is increasing in incidence worldwide. The bacteria in your mouth, like what we are finding to be true of the bacteria in your gut, needs to be balanced to support optimal health. Unfortunately, just like your colon – which, by the way is at end of the same canal (the alimentary canal that begins in the mouth and ends at the rectum) when your oral bacteria becomes overpopulated by “bad” bacteria – bigger and bigger problems arise. The damaging oral bacteria that are there for a reason (food digestion) will start to digest your gums if they aren’t kept under control. First signs are bleeding gums and swelling, usually in local areas like a back molar or two. Next, the involvement will expand to more teeth, with even more observable inflammation that drives below the gum line. Overtime, the bacteria will eat away the structures that hold the tooth in place (detachment) causing the tooth to move to the point that, if left unaddressed – you will lose the tooth. Worse, what’s happening deep in that tooth socket is even more damaging – the bacteria by this point is destroying your jaw bone. All this on its crusade to find a blood supply. And once it breaks into a capillary, vein or artery – away it goes to distant parts of your body and directly into your brain. It is very important to understand that bleeding gums is not normal/natural from ordinary things like: teeth brushing, flossing or eating. According to the CDC, 50% of individuals over the age of 30 have some Periodontal Disease. By the time you are 65, that number is 70%. And the bacteria that is responsible for this destructive disease can be communicated – through sharing utensils, touch and kissing. But where not everyone with Periodontal Disease develops Alzheimer’s Disease, over 70% of patients with Alzheimer’s have Periodontal Disease. Herein is where The Alzheimer’s Legacy Lab comes in. The work our foundation (with your generous donations) is funding will fully explain this phenomena. Tooth Loss is Highly Associated with Dementia Risk The relationship between tooth loss and cognitive decline is “dose-dependent” In a 2021 study, researchers discovered a 1.4% increase in the risk of mild cognitive impairment (MCI) with each lost tooth and a 1.1% increase in the risk of generalized dementia. Participants who were missing 20 (or more) teeth had a 31% higher risk of cognitive impairment and/or dementia.  And there’s some real science to this: Tooth extractions allow oral bacterial to get into the blood stream and into the brain Extracting a tooth creates a 1″ deep hole from your mouth to your jaw bone. And for an adult, this hole takes anywhere from 3 months to 1 year to fully heal…longer if your are older, even longer if you suffer from Diabetes. Net/net – tooth loss increases your Alzheimer’s risk by creating (and leaving) an open access point to your body’s blood supply for oral bacteria to go where ever your blood takes it. So when you think about exposure, the longer it takes to close this hole, the more oral bacteria can get into your blood stream.  Especially when you consider that all along the inside of the extraction site there are small blood vessels that can transport oral bacteria out of the mouth and into the body and brain. More importantly, the jaw bone where the tooth gained it’s blood supply is fed by arteries.  And no kidding: these same arteries also feed the brain.   The healing time of an extraction site depends on a few factors: the type of tooth that’s extracted, the trauma associated with the extraction (simple or surgical), and – you guessed it – your age.   And to make matters worse, as the study above indicated, your risk of developing dementia (including Alzheimer’s Disease) increases with every tooth you lose.   And think about it – there are two things most people living in memory care share – dementia and dentures!  That’s not coincidental.  That’s a white flag waiting to be someone else’s “aha moment”.  It’s certainly been ours.   So consider this tip for Preventing Alzheimer’s the next time you’re at the dentist and there’s a choice to save your tooth or have it pulled. If having dentures  – and subsequently losing them at your nursing home – wasn’t such a big deal, then Universities wouldn’t be spending so much money trying to devise a better plan to find the dentures that…their AD patients keep losing.  This fact should be a signal to other researchers studying Alzheimer’s Disease – that tooth loss must be an Alzheimer’s Risk Factor.  And it is.  Our own research within the 10,000+ patient base that our dental clinic in Saint Paul Minnesota served proved time and time again that losing a tooth later in life was a great predictive factor for the development of dementia – including Alzheimer’s Disease.   This study  lends support to the fascinating association that tooth loss increases your Alzheimer’s risk. The study’s conclusion was that older adults that lose a tooth are particularly vulnerable to negative cognitive effects.  Periodontal Disease = Tooth Loss Many adults lose teeth to injury or break down.  But Periodontal Disease (PD) remains the number one cause of tooth loss in the adult population.  In looking at Alzheimer’s Risk Factors – you’ll see that Periodontal Disease is in the top 5 comorbid  conditions for AD.  Why is that? Visit this article on the connection between tooth loss and AD Find out more One Final Note: At some point, dentistry will need to address this connection between tooth loss

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Know your Alzheimer’s Risk: #1 is Age

Based on our knowledge and experience, here’s what we think you would want to know about Late Onset Alzheimer’s Disease (LOAD). In a follow up article (Part II), we will offer advice gained from experience and current literature that can help you possibly slow the disease down until a Cure is available for widespread use. But for now, we’d like you to – 1) Know that there are two forms of Alzheimer’s – Early Onset Alzheimer’s Disease and Late Onset Alzheimer’s Disease. Early Onset (which is rare) occurs before age 65. Late Onset Alzheimer’s (which is what most of us think of when talking about Alzheimer’s) occurs after age 65. (1) This article focuses on this second form of Alzheimer’s Disease. 2) Know that without an autopsy, a clear-cut diagnosis for this disease is impossible. Therefore, it’s critical that other medical reasons that can look like early-stage Alzheimer’s disease have been ruled out. Conditions with similar cognitive symptoms include: depression, stress, diabetes, thyroid disfunction, liver or kidney disease, vitamin deficiencies, even exposure to low levels of carbon monoxide. These are easy tests to perform and will give you the reassurance that a presumed Alzheimer’s diagnosis is truly accurate. 3) Know that Primary Care/Family Practice/Internists are in no position to diagnose AD– and after ruling out all medical and psychological explanations for your decline – their duty is to refer you to a Neurologist for further testing and treatment. 4) Know that many people over the age of 60 have some Alzheimer’s pathology already in their brains (2a) and yet they show no signs of cognitive impairment. So, you have more and are seeing a decline in your ability to think – it’s time to do something about it. 5) Know that Alzheimer’s Disease is generally contracted 10-15 years before symptoms force a diagnosis. The median age for diagnosis is 79.9 (2), therefore the median age for contracting this disease is estimated to be 65-70 years of age. 6) Know that one of the top risk factors for Alzheimer’s is having gum disease. (3) (4) A fact long suspected in Dentistry, and just now entering the science community. 7) Know that Alzheimer’s Disease skyrockets 10-15 years after a country changes their position on prophylactic antibiotics during dental procedures. It’s too consistent to be coincidental. 8) Know that Alzheimer’s Disease began to skyrocket 10-15 years after our medical community stopped endorsing Hormone Replacement Therapy for post-menopausal women. 9) Know that most auto-immune diseases that are considered risk factors for Alzheimer’s are risk factors because they overlap with the higher risk that gender plays in contracting Alzheimer’s. Being female increases your risk of contracting Alzheimer’s substantially. And women make up the bulk of those diagnosed with Sjogren’s Syndrome, Rheumatoid Arthritis, Lupus, even type II diabetes that strikes after menapause. 10) Know that aging is your number one risk for contracting late-onset Alzheimer’s Disease. This is LARGELY because of something called Senescence – which is defined as the loss of our cell’s ability to divide and grow. This, in turn affects every biological system in your body – in the instance of Alzheimer’s Disease, senescence impedes your brain’s ability to protect itself from foreign pathogens like bacteria. 11) Know that Alzheimer’s is a disease of inflammation. Which is why the most commonly prescribed Alzheimer’s drugs (that have been shown to reduce brain inflammation), seem to work initially (5). But as the diseased brain becomes more inflamed, the effectiveness of these drugs quickly becomes insufficient. Which is why you should …. 12) …Know that research continues to prove that current Alzheimer’s drugs have little to no positive effect (6). Yet these drugs come with a very serious list of side effects. Therefore, you should be challenging your provider to show you the studies that support his/her recommendation that you should be taking these drugs. You will find that no Alzheimer’s drug has been studied longer than 5 years. So, no one really knows what they are doing to your brain’s chemistry long-term. 13) Know that the idea that Alzheimer’s is inherited can be disproven by statistic– 70% of Late Onset Alzheimer’s Disease (LOAD) cases have no family history for Alzheimer’s (7). So, it’s time to stop blaming genetics and time to start looking for what you can do now. Stay tuned for our second article in this series that will help offer ideas on what you can do now to potentially protect yourself against Alzheimer’s Disease. Feel free to visit our website at www.CuringAlzheimersDisease.comfor more information, and be sure to subscribe to this blog www.Curing-Alzheimer’s.com for updates on what is published next. # # # Citations: (1) Types of Alzheimer’s Disease (2a) Non-Demented Individuals with Alzheimer’s Disease Neuropathology: Resistance to Cognitive Decline May Reveal New Treatment Strategies (2016) (2) Time from diagnosis to institutionalization and death in people with dementia (2020) (3) ) Oral bacteria may be responsible for Alzheimer’s disease – Harvard University 2019 (4) Large study links gum disease with dementia – NIH 2020 https://www.nia.nih.gov/news/large-study-links-gum-disease-dementia#:~:text=Among%20those%2065%20years%20or,to%20further%20increase%20those%20risks (5) Donepezil doesn’t cure Alzheimers, it just treats AD inflammation 2020 (6) Current Alzheimer’s drugs do little to help patients – 2020 (7) Maternal transmission of Alzheimer’s disease: Prodromal metabolic phenotype and the search for genes About the author: Anna Shelander is a journalist and question-asker who rarely accepts “no” for an answer. Which is why, when her dad (Dr. Crandall ) became ill with an unexplainable disease, he asked her to come along for the ride. The two worked unsuccessfully within the medical community to find a diagnosis, then branched into the research community where answers finally began to appear. It was at this level of science that Anna and her father began to parse together the drug protocols that dramatically improved his cognition. Disclaimer No content on this site, regardless of date, should ever be used as an absolute substitute for direct medical advice from your doctor or other qualified clinician. This article should be viewed as advice that is based on current research regarding the potential to slow and possibly prevent Alzheimer’s Disease.  Copyright © 2022 Curing Alzheimer’s Disease [EIN #88-3154550]  All Rights Reserved.  This information is not designed to replace a physician’s independent judgment about the appropriateness

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